Renal cell carcinoma Fuhrman grade 2

Figure A. H&E x10

Figure B. CA-IX

Figure C. CK7

Figure D. Racemase

Figure E. TEF3

 

   

 

Clinical History: 29-year-old male with history of adrenocortical carcinoma. He has had prior chemotherapy and radiation to his left upper quadrant and has had a prior adrenalectomy for a large adrenocortical cancer. Now, the patient has a mass on the anterior surface of his left kidney.

Histology: Sections show renal cell carcinoma, clear cell type with papillary architecture, Fuhrman nuclear grade 2/4. Special IHC staining for CA-IX in figure B shows patchy staining of tumor cell membranes. Additional IHC staining for CK7 is patchy positive in the papillary aspects of the tumor (Figure C). Staining for racemase is strongly positive in the tumor cells (Figure D). Staining for TFE3 is focally positive in tumor cell nuclei (Figure F). This antigenic profile suggests the presence of a renal cell carcinoma with papillary architecture. 

 


(Last Edition: February 21, 2024 )