Renal Cell Carcinoma Fuhrman grade 4

Figure A. Gross section

Figure B. Gross section

Figure C. H&E x20

Figure D. H&E x40

Figure E. H&E x40

 

   

 

Clinical History: 70-year-old female with large renal cell carcinoma with invasion of the vena cava

Gross section: The cut surface of the kidney shows a red-yellow mottled tumor which involves the renal sinus and extends up to but not through the renal capsule.

Histology: Figures C, D, E show renal cell, carcinoma clear cell type with bizarre nuclei which are multilobular and are 20 µm or greater in size. Nucleoli are prominent and the chromatin is clumped (Fuhrman grade 4).


(Last Edition: February 21, 2024 )