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Clinical
History:
72-year-old man with history of von
Hippel-Lindau disease and thyroid cancer, with bilateral
renal cysts and chronic kidney disease. Patient
underwent right partial nephrectomy to remove the
lesion.
Histology:
The
sections show papillary renal carcinoma with patchy
clear cell component. There is variegated appearance and
discrete papillary fronds lined by neaoplastic
epithelial cells. Cells are cuboidal to low columnar,
basophilic with scant cytoplasm. Figure C shows presence
of foamy macrophages. Special stains in Figure G and H
show tumor cells strongly positive for CK7 in the areas
with papillary configuration and negative in the areas
of clear cell differentiation, focal reactivity for CA-IX
in the areas of clear cell differentiation.
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