Chronic Allograft Rejection

Figure A. H&E x40

Figure B. PAS x40

Figure C. Trichrome stain

Figure D. Trichrome stain

Figure E. Trichrome stain

Figure F. C4d

   

 

Clinical History: An 18-year-old with renal transplant developed acute kidney infection.

Histology: Figure A shows inflammatory cells within glomerular capillary loops and increase in mesangial cellularity. PAS stain in figure B shows double contours and thickening of glomerular capillary walls. Tubular atrophy and interstitial fibrosis as shown by the trichrome stains in Figures C, D and E. Special immunoperoxidase staining for C4d shows focal areas of strong staining in the endothelium of capillary vessels.


(Last Edition: February 21, 2024 )