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Clinical History: A
38 year old female with known history of lupus
erythematosus. She was previously treated for lupus
nephritis. Creatinine is normal but proteinuria has been
rising over past 3 months.
Histology:
The glomeruli show variable increases in mesangial
matrix and cellularity. Figures C and D show thickened
peripheral capillary loops with spike-and-dome
formations and focal segmental basement membrane
reduplication. The tubules lie back-to-back without
significant interstitial fibrosis or inflammation
(Figure B).
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