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Clinical history:
45 year old male presented with hematuria and decreased
urine output and was diagnosed with with rapidly
progressive glomerulonephritis with positive ANCA.
Histology:
The glomeruli
in Figures A and B show solid and hypercellular
architecture with focal necrosis and prominent cellular
crescents. The surrounding interstitial space shows
moderate edema and minimal inflammatory infiltrate.
These findings along with positive ANCA are consistent
with Pauci-immune necrotizing and crescentic
glomerulonephritis, a type of rapidly progressive
glomerulonephritis |
